![]() Gmelin Handbuch der anorganischen Chemie (8.Gmelins Handbuch der anorganischen Chemie (8.(1964) The Radiochemistry of Radium, Subcommittee on Radiochemistry, National Academy of Sciences "Carcinoma of the Trachea Treated by Radon Seed Implantation". Berichte der Deutschen Chemischen Gesellschaft (A and B Series). "Löslichkeits-Bestimmungen einiger Radiumsalze". Zeitschrift für anorganische und allgemeine Chemie. "Revision des Atomgewichtes des Radiums". One dose (50 kBq/kg) in an adult is about 60 nanograms this amount is 1/1000 the weight of an eyelash (75 micrograms). Radium-223 chloride is one of the most potent ((antineoplastic drugs)) known. Bayer received FDA approval for this drug to treat prostate cancer osteoblastic bone metastases in May 2013. Radium-223 dichloride ( USP, radium chloride Ra 223), tradename Xofigo (formerly Alpharadin), is an alpha-emitting radiopharmaceutical. It was also used in medicine to produce radon gas which in turn was used as a brachytheraputic cancer treatment. The large quantities of material involved (to extract a gram of pure radium metal, about 7 tonnes of pitchblende is required) favour this less costly (but less efficient) method over those based on radium bromide or radium chromate (used for the later stages of the separation). Radium chloride is still used for the initial stages of the separation of radium from barium during the extraction of radium from pitchblende. Ĭontrary to diamagnetic barium chloride, radium chloride is weakly paramagnetic with a magnetic susceptibility of 1.05 ×10 6. Gaseous RaCl 2 shows strong absorptions in the visible spectrum at 676.3 nm and 649.8 nm (red): the dissociation energy of the radium–chlorine bond is estimated as 2.9 eV, and its length as 292 pm. Radium chloride is only sparingly soluble in azeotropic hydrochloric acid and virtually insoluble in concentrated hydrochloric acid. This property is used in the first stages of the separation of radium from barium by fractional crystallization. It is less soluble in water than other alkaline earth metal chlorides – at 25 ☌ its solubility is 245 g/L whereas that of barium chloride is 307 g/L, and the difference is even larger in hydrochloric acid solutions. Its color gradually changes to yellow with aging, whereas contamination by barium may impart a rose tint. Radium chloride is a colorless salt with a blue-green luminescence, especially when heated. It can produced by treating radium carbonate with hydrochloric acid. Radium chloride can also be prepared by heating radium bromide in a flow of dry hydrogen chloride gas. If the presence of other anions is suspected, the dehydration may be effectuated by fusion under hydrogen chloride. The dihydrate is dehydrated by heating to 100 ☌ in air for one hour followed by 5.5 hours at 520 ☌ under argon. Radium chloride crystallises from aqueous solution as the dihydrate. The first preparation of radium metal was by the electrolysis of a solution of this salt using a mercury cathode. Marie Curie and André-Louis Debierne used it in their original separation of radium from barium. It was the first radium compound isolated in a pure state. It is a radium salt of hydrogen chloride. Radium chloride is an inorganic compound with the chemical formula Ra Cl 2. ![]()
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